--- title: VarSome API Update - V 11.1.6 description: VarSome API updates to include updates from VarSome 10.3 and VarSome 11.1 including ACMG classifier refinements and improved reporting of drugs and therapies in the AMP classifier. image: https://updates.varsome.com/hubfs/GV_1200x628_BioInformatics.jpg --- [![VarSome](https://updates.varsome.com/hubfs/VarSome_February2020%20Theme/Images/logo.png)](https://varsome.com/) - Editions - [More about VarSome.com](https://varsome.com/varsome-editions/varsome/) - [More about VarSome Premium](https://varsome.com/varsome-editions/varsome-premium/) - [More about VarSome Clinical](https://varsome.com/varsome-editions/varsome-clinical/) - [Learn more about APIs](https://varsome.com/information/varsome-api-info/) - About - Resources - [Library](https://varsome.com/library/) - [Documentation](https://docs.varsome.com/) - [Query types](https://varsome.com/about/examples/) - [IVDR](https://landing.varsome.com/ivdr-whitepaper) - [Germline Classification](https://varsome.com/about/resources/acmg-implementation/) - [Somatic Classification](https://varsome.com/about/resources/amp-implementation/) - Partners - [Distributors](https://varsome.com/distributors/) - [Partners](https://varsome.com/partners/) - [Become a partner](https://landing.varsome.com/become-varsome-partner) - General - [The Company](https://saphetor.com/about/) - [Cite VarSome](https://varsome.com/about/varsome-citations/) - [Link to VarSome](https://varsome.com/how-do-i-create-link-varsome/) - [Contact](https://landing.varsome.com/contact) - [Community](https://varsome.com/community-contributions/) - [Blog](https://blog.varsome.com/) [Platform Updates](https://updates.varsome.com/en/tag/platform-updates) [VarSome API](https://updates.varsome.com/en/tag/varsome-api) # VarSome API Update - V 11.1.6 By [Richard Meyer](https://updates.varsome.com/en/author/richard-meyer) on February, 11 2022 ### Categories - Select a Topic - [All](https://updates.varsome.com/en) - [Platform Updates](https://updates.varsome.com/en/tag/platform-updates) - [VarSome Clinical](https://updates.varsome.com/en/tag/varsome-clinical) - [VarSome API](https://updates.varsome.com/en/tag/varsome-api) - [Release](https://updates.varsome.com/en/tag/release) - [VarSome.com Premium](https://updates.varsome.com/en/tag/varsome-com-premium) - [VarSome.com](https://updates.varsome.com/en/tag/varsome-com) - [ACMG](https://updates.varsome.com/en/tag/acmg) ### Stay up to date ##### Search The Blog [Back to main Blog](https://updates.varsome.com/en) ![](https://updates.varsome.com/hs-fs/hubfs/richard.jpg?height=100&name=richard.jpg) ###### Richard Meyer CTO On Friday **11th March 2022**, the VarSome Stable API ([stable-api.varsome.com](http://stable-api.varsome.com/)) will be updated from version [**10.2.6**](https://updates.varsome.com/en/varsome-api-update-v-10.2.6) to version **11.1.6** with data frozen as of the **4th February 2022**.  This version will be available for testing on the Staging API ([staging-api.varsome.com](http://staging-api.varsome.com/)) from **Friday 11th February 2022**. The most recent version, used by VarSome itself, is always available at [api.varsome.com](http://api.varsome.com/). We strongly encourage you to **test your own use of the VarSome API** against the Staging API over the next four weeks, and let us know if you encounter any unexpected difficulties. # Functional Changes There have been two releases of the VarSome platform in the intervening time, please see the full release notes here for each of these releases - [VarSome 10.3](https://updates.varsome.com/en/varsome-10.3-release-notes) - [VarSome 11.1](https://updates.varsome.com/en/varsome-11.1-release-notes) Highlights in this API update include: - Many refinements to the ACMG classifier - Improved reporting of drugs and therapies in the AMP classifier # Data Format Changes The “Saphetor Known Pathogenic” database which contains all clinically reported variants (see [Clinical Evidence](https://varsome.com/about/resources/acmg-implementation/#clinicalevidence)) has some additional fields: - **transcript**: the transcript picked by the ACMG classifier to classify this variant - **gene\_symbol**: the gene symbol for that transcript - **codon**: the number of the affected codon within that transcript - **hgvs**: the HGVS notation for the variant, where applicable, without the gene name - **disease\_name**: the list of conditions reported by the source database for this variant # Database Updates The following databases have updated contents which will remain frozen till the next Stable API release. | Data Source | Current Version (Stable) | New Version (Staging) | Comment | | --- | --- | --- | --- | | UNIPROT UniProt Regions | 13-Jul-2021 | 7 Dec 2021 | | | NCBI ClinVar CNVs | 07-Oct 2021 | 07-Dec-2021 | | | Sanger DECIPHER | 07-Oct-2021 | 11-Nov-2021 | | | RefSeq Transcripts | 208 | 209 | | | Ensembl Transcripts | 104 | 105 | | | NCBI ClinVar | 07-Oct-2021 | 07-Dec-2021 | | | UniProt Variants | 13-Jul-2021 | 09-Dec-2021 | | | WUSTL CIViC | 07-Oct-2021 | 10-Dec-2021 | | | NIH GDC | 13-Oct-2021 | 13-Dec-2021 | | | Saphetor Known Pathogenic | 01-Nov-2021 | 04-Feb-2021 | Contains additional fields for each variant entry. | | PharmGKB | 16-Sep-2021 | 11-Nov-2021 | | | ACMG Annotation | 10.2.6 | 11.1.6 | | | AMP Annotation | 10.2.6 | 11.1.6 | | | CNV Annotation | 10.2.6 | 11.1.6 | | | JAX CKB | 20-Sep-2021 | 15-Dec-2021 | | | CGD | 15-Jun-2021 | 11-Nov-2021 | | | AACT | 07-Sep-2021 | 13-Dec-2021 | | | GHR Genes | 20-Oct-2021 | 10-Dec-2021 | | | Genomics England PanelAPP | 13-Oct-2021 | 10-Dec-2021 | | | Fusion GDB | 21-Sep-2021 | 19-Nov-2021 | | | ClinGen Gene | 01-Jul-2021 | 20-Dec-2021 | | | GWAS | 13-Oct-2021 | 10-Dec-2021 | | ### Further Information and Support An overview of the VarSome API is available [here](https://varsome.com/information/varsome-api-info/) with more detailed information [here](https://api.varsome.com/). Please contact us at the usual address [support@varsome.com](https://docs.varsome.com/en/kb-tickets/new) should you require any additional information or run into any major issues. As ever we look forward to your feedback and suggestions to improve our platform. 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