--- title: VarSome & VarSome Clinical v.12.5.1 description: 12.5.1 introduces updates in the Region Browser, the transcript information display, and ClinVar submission improvements for VarSome Clinical users. image: https://updates.varsome.com/hubfs/release%20banner%20(2).png --- [![VarSome](https://updates.varsome.com/hubfs/VarSome_February2020%20Theme/Images/logo.png)](https://varsome.com/) - Editions - [More about VarSome.com](https://varsome.com/varsome-editions/varsome/) - [More about VarSome Premium](https://varsome.com/varsome-editions/varsome-premium/) - [More about VarSome Clinical](https://varsome.com/varsome-editions/varsome-clinical/) - [Learn more about APIs](https://varsome.com/information/varsome-api-info/) - About - Resources - [Library](https://varsome.com/library/) - [Documentation](https://docs.varsome.com/) - [Query types](https://varsome.com/about/examples/) - [IVDR](https://landing.varsome.com/ivdr-whitepaper) - [Germline Classification](https://varsome.com/about/resources/acmg-implementation/) - [Somatic Classification](https://varsome.com/about/resources/amp-implementation/) - Partners - [Distributors](https://varsome.com/distributors/) - [Partners](https://varsome.com/partners/) - [Become a partner](https://landing.varsome.com/become-varsome-partner) - General - [The Company](https://saphetor.com/about/) - [Cite VarSome](https://varsome.com/about/varsome-citations/) - [Link to VarSome](https://varsome.com/how-do-i-create-link-varsome/) - [Contact](https://landing.varsome.com/contact) - [Community](https://varsome.com/community-contributions/) - [Blog](https://blog.varsome.com/) [Platform Updates](https://updates.varsome.com/en/tag/platform-updates) [VarSome API](https://updates.varsome.com/en/tag/varsome-api) [VarSome Clinical](https://updates.varsome.com/en/tag/varsome-clinical) [VarSome.com Premium](https://updates.varsome.com/en/tag/varsome-com-premium) [Release](https://updates.varsome.com/en/tag/release) # VarSome & VarSome Clinical v.12.5.1 By [Carl Smith](https://updates.varsome.com/en/author/carl-smith) on October, 17 2024 ### Categories - Select a Topic ### Stay up to date ##### Search The Blog [Back to main Blog](https://updates.varsome.com/en) ![](https://app.hubspot.com/settings/avatar/409171fee064910b6bf04363a7781f22) ###### Carl Smith Version 12.5.0 of VarSome and [VarSome Clinical](https://landing.varsome.com/varsome-clinical) was released on 12 October 2024. Version 12.5.1 of VarSome and VarSome Clinical was released on 17 October 2024. # Summary of Key New Features #### VarSome Clinical - Improved mitochondrial variant calling - Rearrangements on the VarSome Clinical menu - Variant exporting and reporting updates - Variant prioritization for trios with VarSome Picks - CNV analysis filtering to gene lists  - Analysis unarchiving (Only available to accounts not using tokens) #### VarSome - Users can see how many queries they have submitted to VarSome # New Features ## VarSome Clinical #### Improved mitochondrial variant calling We have enhanced our pipeline to improve the detection of low allelic balance mitochondrial variants. This is now available on-demand for testing purposes. If you would like to activate this module, please contact [support@varsome.com](mailto:support@varsome.com). This will be fully integrated into germline pipelines, supporting both single and multi-sample analyses, in the coming months for all users. For more information on how VarSome Clinical identifies mitochondrial variants and how you can apply filters, please visit [https://docs.varsome.com/en/mitochondrial-variant-calling](https://docs.varsome.com/en/mitochondrial-variant-calling).   #### Rearrangements on the VarSome Clinical menu We have updated the Launch Analysis menu in VarSome Clinical to make it easier and clearer to work through the steps required:![Untitled presentation (1) (1)](https://updates.varsome.com/hs-fs/hubfs/Untitled%20presentation%20(1)%20(1).png?width=624&height=264&name=Untitled%20presentation%20(1)%20(1).png)![Untitled presentation (2)](https://updates.varsome.com/hs-fs/hubfs/Untitled%20presentation%20(2).png?width=624&height=237&name=Untitled%20presentation%20(2).png)   #### Variant exporting The process of variant export has now been split into two components, allowing users to choose which variants should be exported to a clinical report and which to an excel file. For spreadsheet exporting, users can easily select their variants from the variant table. The selected variants will be highlighted in yellow. ![](https://lh7-rt.googleusercontent.com/docsz/AD_4nXe_GRryxVERXuJYP_AOkoIaALsQNRZMaR9WyfRe-irCtrNWWSCnJaET9D33mez7fdqHlp_5FQK8wODVX8Hv9E8LG1LJ0dtx8V_82HQ89dWFLbTnjAi6YnyUId6a1luEK8tsB26EWFcjIhlWbleJYn-su7M?key=8JUOzJCzdBmpULNw9uYB6w) For clinical reports, users can label variants as primary or secondary findings. The variants will then be automatically added to the relevant section of the clinical report. ![](https://lh7-rt.googleusercontent.com/docsz/AD_4nXdWXlT26fz8ovT_8vGQ_tW4v8Wz1Ac7XPlS_hLnXJlW25vxF9q_zVX4ulJpsV5KUEf29lJiSheAHYumOTqtPYD1pvT0V8KDjjagSGdI7s2IOk7Brk7x1Hhsez5meICtzsbN_LYXZtVFY04buujaxO26EkY?key=8JUOzJCzdBmpULNw9uYB6w)   #### Variant prioritization for trios Our phenotype-driven variant prioritization algorithm ([VarSome Picks](https://docs.varsome.com/en/varsome-picks)) now extends to support family trio analyses. This algorithm can help users working with family trios in identifying the most likely causative variants related to the proband’s observed phenotypes. ![](https://lh7-rt.googleusercontent.com/docsz/AD_4nXecpsetxESlvP8j2bAIG4NdREIqd2MbiftxXU2EyFDMB1faBkdaT8usr7BMfoviCVfs4gfE4alTwednTtVDogZDwBtaGGdVtzjETmRNOhAssrDdJNGJuoShVGoZw1AgTHTM6GJ6EsIGTw65-xk1qZzOPb8?key=8JUOzJCzdBmpULNw9uYB6w) Please be aware that this filter can only be used for family trio analyses conducted from this point onward and cannot be retroactively applied to past analyses.   #### CNV analysis filtering [Gene lists](https://docs.varsome.com/en/create-a-gene-list) can now be applied to filter the results of [CNV analysis](https://docs.varsome.com/en/cnv/sv-annotation-from-vcf) in VarSome Clinical. ![image (17) (1) (1)](https://updates.varsome.com/hs-fs/hubfs/image%20(17)%20(1)%20(1).png?width=508&height=318&name=image%20(17)%20(1)%20(1).png) The ability to filter genes allows clinicians to focus on genes of interest. This also offers the opportunity to restrict displayed genes to avoid identification of incidental findings. #### Analysis unarchiving Users can now unarchive their analyses without the need to contact Support. ![](https://lh7-rt.googleusercontent.com/docsz/AD_4nXcqBw5zWBAFEj8eqA8UR-dYpznoD1BM5L-WEglxBbP7SumkfwcXGEFLdyyf-KGwY_YpeWhJXWEGtye8vaAdVKYflntULePcvvpdigtWl0qDmNF1PbtpIondO7ceh6lo3c_kAd3ax9vW4OL6qN0b1tCAFYk?key=8JUOzJCzdBmpULNw9uYB6w) Additional charges are applied for unarchiving analyses. This feature is only available to accounts not using tokens. ## VarSome #### Usage tracking Users can now see the number of queries they have performed each month.![](https://lh7-rt.googleusercontent.com/docsz/AD_4nXeHAkMVyzVKKtpp9WYa8Rph3swUbicGsdIFrywyMeYklkwD5WIQEKvg3NLhwWJwwIXt7ip0ISAL27362JOu5TuWHi9qCv7ImuUahrLka1qQivZQEy-LpawKBxP-EIst2wBV8OHTw3UVjCeAmLCnlusxDH4?key=8JUOzJCzdBmpULNw9uYB6w)   Version 12.5.1 of VarSome and VarSome Clinical was released on 17 October 2024. ## Summary of Key New Features - **Region Browser update of the UniProt Protein Region** "homo\_sapiens proteome sequences" are now hidden from the Region Browser view - **Improvements to HGVS notation according to the HGVS nomenclature** - **ClinVar Submission improvements on VarSome Clinical** VarSome Clinical users can now see their ClinVar submitted forms - **Publications sorting update on the** [**Citations Page**](https://varsome.com/about/general/varsome-citations/) Users can now sort the publications by ‘Publication Date’ - **Transcript view improvements** When searching for genes, available transcripts are now displayed with relevant variant location information in the title #### Support We hope you find these improvements helpful. We would love to hear any feedback and suggestions you may have. Support is available as usual from [support@varsome.com.](mailto:support@varsome.com)   The VarSome Team. 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