VarSome API Update - v. 13.16.1

Written by Xanthippi Papakonstanti | May 13, 2026 8:50:05 AM

On 5th June 2026 we will be releasing the Q2 API changes for the VarSome API (stable-api.varsome.com).

The Stable API will update version 13.14.1 to version 13.16.1.0 with data frozen as of the 8th May 2026. This version has been successfully used in production for over a month.

The most recent version, used by VarSome itself, is always available at api.varsome.com.

Database Updates

The following databases have been updated:

Source	Data Type	Current version (Stable, Q1 '26)	Next release (Staging, Q2 '26)
ACMG classifier	variant	13.14.1	13.15.2
AMP classifier	variant	13.14.1	13.15.2
AACT	Gene	07-Jan-2026	07-Apr-2026
CKB	Somatic Variants	19-Jan-2026	14-Apr-2026
CPIC	Gene	07-Jan-2026	07-Apr-2026
CancerGeneCensus	Gene	v102	v103
ClinGen	Gene	07-Jan-2026	07-Apr-2026
ClinGenCNVs	Genomic Regions	07-Jan-2026	07-Apr-2026
ClinGenDiseaseValidity	Gene	07-Jan-2026	07-Apr-2026
ClinGenRegions	Genomic Regions	07-Jan-2026	07-Apr-2026
ClinGenVariants	Germline Variants	07-Jan-2026	07-Apr-2026
ClinVar	Germline Variants	07-Jan-2026	07-Apr-2026
ClinVarCNVs	Genomic Regions	07-Jan-2026	07-Apr-2026
Conrad et al., 2010	Genomic Regions	N/A	12-Mar-2026
Cosmic	Germline Variants	v102	v103
CosmicGeneFusions	Gene	v102	v103
DECIPHER	Genomic Regions	07-Jan-2026	07-Apr-2026
DGV	Genomic Regions	30-Jun-2021	07-Apr-2026
GA4K	Genomic Regions	N/A	12-Mar-2026
GHR	Gene	07-Jan-2026	07-Apr-2026
GWAS	Germline Variants	07-Jan-2026	07-Apr-2026
HPO	Diseases & Phenotypes	07-May-2025	07-Apr-2026
HPRCSVs	Genomic Regions	N/A	12-Mar-2026
IraMHallLabSVs	Genomic Regions	N/A	12-Mar-2026
LOVD	Germline Variants	19-Jan-2026	14-Apr-2026
OMIM®	Diseases & Phenotypes	19-Jan-2026	14-Apr-2026
OncoKB	Gene	v5.4	v7.0
OncoTree	Diseases & Phenotypes	15-Jan-2024	06-Feb-2026
Pfam	Genomic Regions	N/A	07-Apr-2026
PharmGKB	Germline Variants	07-Jan-2026	07-Apr-2026
SpliceVarDB	Germline Variants	N/A	07-Feb-2026
UniProtRegions	Genomic Regions	07-Nov-2025	07-Feb-2026
UniProtVariants	Germline Variants	07-Jul-2025	07-Feb-2026
cBioPortal	SomaticVariants	06-Jun-2023	07-Mar-2026
dbNSFP	Gene	5.2	5.3
dbNSFP	Germline Variants	5.2	5.3
dbVar	Genomic Regions	07-Nov-2025	07-Feb-2026
gene2phenotype	Gene	07-Jan-2026	07-Apr-2026

JSON Schema Changes

Variants

Modified Endpoints: 2

POST /lookup/batch/{ref_genome}

Request body changed
- Content changed
  - Modified media type: application/json
    - Schema changed
      - Properties changed
        
        Modified property: variants
        
        MaxItems changed from 200 to 50
Responses changed
- Modified response: 201
  - Content changed
    - Modified media type: application/json
      - Schema changed
        
        Properties changed
        
        New property: compbio_splice_var_db
        
        Modified property: regions
        
        Properties changed
        
        New property: children_mercy_research_institute
        
        New property: hprc
        
        New property: ira_m_hall_lab
        
        New property: tcag_conrad_estd20
        
        Modified property: clingen_cnvs
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data
        
        Modified property: clinvarcnv
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data
        
        Modified property: decipher
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data
        
        Modified property: ncbi_dbVar
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data
        
        Modified property: tcag_dgv
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data

GET /lookup/{spec_query}/{ref_genome}

Responses changed
- Modified response: 200
  - Content changed
    - Modified media type: application/json
      - Schema changed
        
        Properties changed
        
        New property: compbio_splice_var_db
        
        Modified property: regions
        
        Properties changed
        
        New property: children_mercy_research_institute
        
        New property: hprc
        
        New property: ira_m_hall_lab
        
        New property: tcag_conrad_estd20
        
        Modified property: clingen_cnvs
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data
        
        Modified property: clinvarcnv
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data
        
        Modified property: decipher
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data
        
        Modified property: ncbi_dbVar
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data
        
        Modified property: tcag_dgv
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data

Genes

Modified Endpoints: 1

POST /genes/batch/{ref_genome}

Request body changed
- Content changed
  - Modified media type: application/json
    - Schema changed
      - Properties changed
        
        Modified property: genes
        
        MaxItems changed from 100 to 10

CNVs

Modified Endpoints: 1

GET /cnv/{query}/{ref_genome}

Responses changed
- Modified response: 200
  - Content changed
    - Modified media type: application/json
      - Schema changed
        
        Properties changed
        
        New property: chosen_cnv_overlap_data
        
        Modified property: regions
        
        Properties changed
        
        New property: children_mercy_research_institute
        
        New property: hprc
        
        New property: ira_m_hall_lab
        
        New property: tcag_conrad_estd20
        
        Modified property: clingen_cnvs
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data
        
        Modified property: clinvarcnv
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data
        
        Modified property: decipher
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data
        
        Modified property: ncbi_dbVar
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data
        
        Modified property: tcag_dgv
        
        Properties changed
        
        Modified property: items
        
        Items changed
        
        Properties changed
        
        New property: overlap_data

Please contact us if you need any further assistance with this release.

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