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On 5th June 2026 we will be releasing the Q2 API changes for the VarSome API (stable-api.varsome.com).
The Stable API will update version 13.14.1 to version 13.16.1.0 with data frozen as of the 8th May 2026. This version has been successfully used in production for over a month.
The most recent version, used by VarSome itself, is always available at api.varsome.com.
Database Updates
The following databases have been updated:
| Source | Data Type | Current version (Stable, Q1 '26) |
Next release (Staging, Q2 '26) |
|---|---|---|---|
| ACMG classifier | variant | 13.14.1 | 13.15.2 |
| AMP classifier | variant | 13.14.1 | 13.15.2 |
| AACT | Gene | 07-Jan-2026 | 07-Apr-2026 |
| CKB | Somatic Variants | 19-Jan-2026 | 14-Apr-2026 |
| CPIC | Gene | 07-Jan-2026 | 07-Apr-2026 |
| CancerGeneCensus | Gene | v102 | v103 |
| ClinGen | Gene | 07-Jan-2026 | 07-Apr-2026 |
| ClinGenCNVs | Genomic Regions | 07-Jan-2026 | 07-Apr-2026 |
| ClinGenDiseaseValidity | Gene | 07-Jan-2026 | 07-Apr-2026 |
| ClinGenRegions | Genomic Regions | 07-Jan-2026 | 07-Apr-2026 |
| ClinGenVariants | Germline Variants | 07-Jan-2026 | 07-Apr-2026 |
| ClinVar | Germline Variants | 07-Jan-2026 | 07-Apr-2026 |
| ClinVarCNVs | Genomic Regions | 07-Jan-2026 | 07-Apr-2026 |
| Conrad et al., 2010 | Genomic Regions | N/A | 12-Mar-2026 |
| Cosmic | Germline Variants | v102 | v103 |
| CosmicGeneFusions | Gene | v102 | v103 |
| DECIPHER | Genomic Regions | 07-Jan-2026 | 07-Apr-2026 |
| DGV | Genomic Regions | 30-Jun-2021 | 07-Apr-2026 |
| GA4K | Genomic Regions | N/A | 12-Mar-2026 |
| GHR | Gene | 07-Jan-2026 | 07-Apr-2026 |
| GWAS | Germline Variants | 07-Jan-2026 | 07-Apr-2026 |
| HPO | Diseases & Phenotypes | 07-May-2025 | 07-Apr-2026 |
| HPRCSVs | Genomic Regions | N/A | 12-Mar-2026 |
| IraMHallLabSVs | Genomic Regions | N/A | 12-Mar-2026 |
| LOVD | Germline Variants | 19-Jan-2026 | 14-Apr-2026 |
| OMIM® | Diseases & Phenotypes | 19-Jan-2026 | 14-Apr-2026 |
| OncoKB | Gene | v5.4 | v7.0 |
| OncoTree | Diseases & Phenotypes | 15-Jan-2024 | 06-Feb-2026 |
| Pfam | Genomic Regions | N/A | 07-Apr-2026 |
| PharmGKB | Germline Variants | 07-Jan-2026 | 07-Apr-2026 |
| SpliceVarDB | Germline Variants | N/A | 07-Feb-2026 |
| UniProtRegions | Genomic Regions | 07-Nov-2025 | 07-Feb-2026 |
| UniProtVariants | Germline Variants | 07-Jul-2025 | 07-Feb-2026 |
| cBioPortal | SomaticVariants | 06-Jun-2023 | 07-Mar-2026 |
| dbNSFP | Gene | 5.2 | 5.3 |
| dbNSFP | Germline Variants | 5.2 | 5.3 |
| dbVar | Genomic Regions | 07-Nov-2025 | 07-Feb-2026 |
| gene2phenotype | Gene | 07-Jan-2026 | 07-Apr-2026 |
JSON Schema Changes
Variants
Modified Endpoints: 2
POST /lookup/batch/{ref_genome}
- Request body changed
- Content changed
- Modified media type: application/json
- Schema changed
- Properties changed
- Modified property: variants
- MaxItems changed from 200 to 50
- Modified property: variants
- Properties changed
- Schema changed
- Modified media type: application/json
- Content changed
- Responses changed
- Modified response: 201
- Content changed
- Modified media type: application/json
- Schema changed
- Properties changed
- New property: compbio_splice_var_db
- Modified property: regions
- Properties changed
- New property: children_mercy_research_institute
- New property: hprc
- New property: ira_m_hall_lab
- New property: tcag_conrad_estd20
- Modified property: clingen_cnvs
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Modified property: clinvarcnv
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Modified property: decipher
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Modified property: ncbi_dbVar
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Modified property: tcag_dgv
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Properties changed
- Schema changed
- Modified media type: application/json
- Content changed
- Modified response: 201
GET /lookup/{spec_query}/{ref_genome}
- Responses changed
- Modified response: 200
- Content changed
- Modified media type: application/json
- Schema changed
- Properties changed
- New property: compbio_splice_var_db
- Modified property: regions
- Properties changed
- New property: children_mercy_research_institute
- New property: hprc
- New property: ira_m_hall_lab
- New property: tcag_conrad_estd20
- Modified property: clingen_cnvs
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Modified property: clinvarcnv
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Modified property: decipher
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Modified property: ncbi_dbVar
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Modified property: tcag_dgv
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Properties changed
- Schema changed
- Modified media type: application/json
- Content changed
- Modified response: 200
Genes
Modified Endpoints: 1
POST /genes/batch/{ref_genome}
- Request body changed
- Content changed
- Modified media type: application/json
- Schema changed
- Properties changed
- Modified property: genes
- MaxItems changed from 100 to 10
- Modified property: genes
- Properties changed
- Schema changed
- Modified media type: application/json
- Content changed
CNVs
Modified Endpoints: 1
GET /cnv/{query}/{ref_genome}
- Responses changed
- Modified response: 200
- Content changed
- Modified media type: application/json
- Schema changed
- Properties changed
- New property: chosen_cnv_overlap_data
- Modified property: regions
- Properties changed
- New property: children_mercy_research_institute
- New property: hprc
- New property: ira_m_hall_lab
- New property: tcag_conrad_estd20
- Modified property: clingen_cnvs
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Modified property: clinvarcnv
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Modified property: decipher
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Modified property: ncbi_dbVar
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Modified property: tcag_dgv
- Properties changed
- Modified property: items
- Items changed
- Properties changed
- New property: overlap_data
- Properties changed
- Schema changed
- Modified media type: application/json
- Content changed
- Modified response: 200
Please contact us if you need any further assistance with this release.
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