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On 5th June 2026 we will be releasing the Q2 API changes for the VarSome API (stable-api.varsome.com).
The Stable API will update version 13.14.1 to version 13.16.1.0 with data frozen as of the 8th May 2026. This version has been successfully used in production for over a month.
The most recent version, used by VarSome itself, is always available at api.varsome.com.
Database Updates
The following databases have been updated:
| Source | Data Type | Current version (Stable, Q1 '26) |
Next release (Staging, Q2 '26) |
|---|---|---|---|
| ACMG classifier | variant | 13.14.1 | 13.15.2 |
| AMP classifier | variant | 13.14.1 | 13.15.2 |
| AACT | Gene | 07-Jan-2026 | 07-Apr-2026 |
| CKB | Somatic Variants | 19-Jan-2026 | 14-Apr-2026 |
| CPIC | Gene | 07-Jan-2026 | 07-Apr-2026 |
| CancerGeneCensus | Gene | v102 | v103 |
| ClinGen | Gene | 07-Jan-2026 | 07-Apr-2026 |
| ClinGenCNVs | Genomic Regions | 07-Jan-2026 | 07-Apr-2026 |
| ClinGenDiseaseValidity | Gene | 07-Jan-2026 | 07-Apr-2026 |
| ClinGenRegions | Genomic Regions | 07-Jan-2026 | 07-Apr-2026 |
| ClinGenVariants | Germline Variants | 07-Jan-2026 | 07-Apr-2026 |
| ClinVar | Germline Variants | 07-Jan-2026 | 07-Apr-2026 |
| ClinVarCNVs | Genomic Regions | 07-Jan-2026 | 07-Apr-2026 |
| Conrad et al., 2010 | Genomic Regions | N/A | 12-Mar-2026 |
| Cosmic | Germline Variants | v102 | v103 |
| CosmicGeneFusions | Gene | v102 | v103 |
| DECIPHER | Genomic Regions | 07-Jan-2026 | 07-Apr-2026 |
| DGV | Genomic Regions | 30-Jun-2021 | 07-Apr-2026 |
| GA4K | Genomic Regions | N/A | 12-Mar-2026 |
| GHR | Gene | 07-Jan-2026 | 07-Apr-2026 |
| GWAS | Germline Variants | 07-Jan-2026 | 07-Apr-2026 |
| HPO | Diseases & Phenotypes | 07-May-2025 | 07-Apr-2026 |
| HPRCSVs | Genomic Regions | N/A | 12-Mar-2026 |
| IraMHallLabSVs | Genomic Regions | N/A | 12-Mar-2026 |
| LOVD | Germline Variants | 19-Jan-2026 | 14-Apr-2026 |
| OMIM® | Diseases & Phenotypes | 19-Jan-2026 | 14-Apr-2026 |
| OncoKB | Gene | v5.4 | v7.0 |
| OncoTree | Diseases & Phenotypes | 15-Jan-2024 | 06-Feb-2026 |
| Pfam | Genomic Regions | N/A | 07-Apr-2026 |
| PharmGKB | Germline Variants | 07-Jan-2026 | 07-Apr-2026 |
| SpliceVarDB | Germline Variants | N/A | 07-Feb-2026 |
| UniProtRegions | Genomic Regions | 07-Nov-2025 | 07-Feb-2026 |
| UniProtVariants | Germline Variants | 07-Jul-2025 | 07-Feb-2026 |
| cBioPortal | SomaticVariants | 06-Jun-2023 | 07-Mar-2026 |
| dbNSFP | Gene | 5.2 | 5.3 |
| dbNSFP | Germline Variants | 5.2 | 5.3 |
| dbVar | Genomic Regions | 07-Nov-2025 | 07-Feb-2026 |
| gene2phenotype | Gene | 07-Jan-2026 | 07-Apr-2026 |
JSON Schema Changes
Variants
POST /lookup/batch/{ref_genome}
- modified the property variants of the request body to accept max 50 items from 200
- added the optional property compbio_splice_var_db to the response with the 201 status
- added the optional property regions/children_mercy_research_institute to the response with the 201 status
- added the optional property regions/clingen_cnvs/items/items/overlap_data to the response with the 201 status
- added the optional property regions/clinvarcnv/items/items/overlap_data to the response with the 201 status
- added the optional property regions/decipher/items/items/overlap_data to the response with the 201 status
- added the optional property regions/hprc to the response with the 201 status
- added the optional property regions/ira_m_hall_lab to the response with the 201 status
- added the optional property regions/ncbi_dbVar/items/items/overlap_data to the response with the 201 status
- added the optional property regions/tcag_conrad_estd20 to the response with the 201 status
- added the optional property regions/tcag_dgv/items/items/overlap_data to the response with the 201 status
GET /lookup/{spec_query}/{ref_genome}
- added the optional property compbio_splice_var_db to the response with the 200 status
- added the optional property regions/children_mercy_research_institute to the response with the 200 status
- added the optional property regions/clingen_cnvs/items/items/overlap_data to the response with the 200 status
- added the optional property regions/clinvarcnv/items/items/overlap_data to the response with the 200 status
- added the optional property regions/decipher/items/items/overlap_data to the response with the 200 status
- added the optional property regions/hprc to the response with the 200 status
- added the optional property regions/ira_m_hall_lab to the response with the 200 status
- added the optional property regions/ncbi_dbVar/items/items/overlap_data to the response with the 200 status
- added the optional property regions/tcag_conrad_estd20 to the response with the 200 status
Genes
POST /genes/batch/{ref_genome}
- modified the property genes of the request body to accept max 10 items from 100
CNVs
Modified Endpoints: 1
GET /cnv/{query}/{ref_genome}
- added the optional property chosen_cnv_overlap_data to the response with the 200 status
- added the optional property regions/children_mercy_research_institute to the response with the 200 status
- added the optional property regions/clingen_cnvs/items/items/overlap_data to the response with the 200 status
- added the optional property regions/clinvarcnv/items/items/overlap_data to the response with the 200 status
- added the optional property regions/decipher/items/items/overlap_data to the response with the 200 status
- added the optional property regions/hprc to the response with the 200 status
- added the optional property regions/ira_m_hall_lab to the response with the 200 status
- added the optional property regions/ncbi_dbVar/items/items/overlap_data to the response with the 200 status
- added the optional property regions/tcag_conrad_estd20 to the response with the 200 status
- added the optional property regions/tcag_dgv/items/items/overlap_data to the response with the 200 status
Please contact us if you need any further assistance with this release.
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