Version 13.17.0.0 of VarSome and VarSome Premium was released on 27 April 2026.

Summary of Key New Features

• Users can now visualize Protein family (PFAM) domain annotations directly within the Fusion Details card, providing structural context for assessing possible functional impact for fusion events at a glance.
• Two new predictive scores from dbNSFP version 5.3 are now available in the in-silico predictor card: MisFit and popEVE.
• Users with COSMIC license can now visualize a table listing all alternative transcripts associated with the selected variant, and a new section surfaces detailed COSMIC sample-level occurrence data for the variant, including metadata for each reported sample.
• Fixed an issue where the 'Gene/Regions overlap' rule was not consistently identifying haploinsufficiency (HI) and loss-of-function (LOF) genes within the overlapping region.
• Fixed an issue where CNV losses affecting the last exon of a gene did not consistently check for other established pathogenic variants reported in that exon.

Support

We hope you find these improvements helpful. We would love to hear any feedback and suggestions you may have. Support is available as usual from support@varsome.com.

The VarSome Team.