Version 13.1.2 of VarSome and VarSome Clinical was released on 15 March 2025 to address minor performance issues:

• Users can now modify phenotypic data, including adding phenotypic data to finished analyses
• Fix of potential failures of multi-sample analyses using existing analyses
• "Sample metrics" column display has been updated
• "CNV Gene Lists" can now be launched from the "Action Menu"
• Refinements were also made to the somatic classifier to address an issue with how Jax CKB determines variant effect that was leading to some variants being incorrectly reported as relevant. We have implemented an overrule to the "Protein Effect" information coming from Jax CKB, whereby if the germline classifier indicates that a variant is Benign or Likely Benign "Protein Effect" data from Jax CKB will not be considered. We have also upgraded Levels Dx2, Dx3, Px2, and Px3 coming from OncoKB to be accounted for as Tier I evidence.

Version 13.1.1 of VarSome and VarSome Clinical was released on 27 February 2025 to address minor display inconsistencies with publication links and optimizing the presentation of variant sample count information.

Version 13.1.0 of VarSome and VarSome Clinical was released on 27 February 2025.

Summary of Key New Features

• 26 updated databases (full list of databases)

Updated Databases

Support

We hope you find these improvements helpful. We would love to hear any feedback and suggestions you may have. Support is available as usual from support@varsome.com.

The VarSome Team.