---
title: Population Allele Frequency Chart
description: Today we are announcing a new feature - Allele Frequencies Chart, combined with the lollipop graph for genes.
---

[VarSome - Platform Updates](https://updates.varsome.com/en)

# [Population Allele Frequency Chart](https://updates.varsome.com/en/population-allele-frequency-chart)

 Written by [Richard Meyer](https://updates.varsome.com/en/author/richard-meyer) | Mar 31, 2020, 9:49:00 AM

Today we are announcing a new feature - Population Allele Frequencies Chart, combined with the lollipop graph for genes, which is now directly visible in [VarSome’s genome browser](https://varsome.com/gene/BICD2#region-browser) using a log scale. This can be useful in parallel with the pathogenicity lollipop graph \[Fig 1\].

*Figure 1. BICD2 Allele frequencies chart.*

> '*[BICD2](https://varsome.com/gene/BICD2) is a gene for which few benign variants have been reported, so population variation is crucial to visualize patterns of disease-causing variants. Notice that the pathogenic/likely pathogenic variants tend to cluster in mutation hotspots with blue-green “spikes” of low frequency population variation. These correspond to BICD2’s key interaction regions where missense variants can be disruptive. Outside of them, missense variants tend to be benign. Very useful to see that recapitulated in VarSome’s plots.*'  says **Daniel C. Koboldt**, Principal Investigator, The Institute for Genomic Medicine at Nationwide Children’s Hospital, and Assistant Professor of Pediatrics, The Ohio State University.

## Let us know what you think!

As ever, we hope you find these new features useful, and look forward to any feedback or suggestions you may have. You may leave a comment right here or [get in touch with us](https://saphetor.com/contact/).

[View full post](https://updates.varsome.com/en/population-allele-frequency-chart)

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