---
title: CNV Calling Enhancements
description: VarSome Clinical v10.2 adds significant upgrades to CNV calling capabilities, including additional quality control and dynamic visualization through our new CNV Broswer.
---

[VarSome - Platform Updates](https://updates.varsome.com/en)

# [CNV Calling Enhancements](https://updates.varsome.com/en/cnv-calling-enhancements)

 Written by [Richard Meyer](https://updates.varsome.com/en/author/richard-meyer) | Sep 22, 2021, 7:54:06 AM

The [v10.2](https://updates.varsome.com/en/varsome-10.2-release-notes) release of [VarSome Clinical](https://landing.varsome.com/varsome-clinical) offers several novel features improving CNV detection, quality control and reporting. A new dynamic CNV browser offers an overall view of the call regions in their genomic context in every co-analysed sample. For detailed information, we recommend that users refer to the User Manual, which is accessible for download via the “Support & Manual” link in VarSome Clinical.

**CNV call quality control - *Explore the quality of each CNV call in depth***

Additional quality data are displayed for each call that allow the user to assess result reliability. Each CNV call is assigned a set of three “traffic-lights”, which are colored green or red, depending on whether the CNV call meets the quality control criteria. These are:

- **Test sample coverage** to ensure a minimum coverage of the test sample at the CNV call region when calling duplications.
- **Number of reference samples** to satisfy a minimum number (2) of samples from the reference set with a minimum coverage in the CNV call region.
- **Camouflaged region** **overlap** checks whether a CNV call falls within a genomic [Camouflaged Region](https://dx.doi.org/10.1186%2Fs13059-019-1707-2), which typically contain duplicated genomic sequences.

 

**CNV Browser - *Gain further insight with a dynamic visualization***

A novel, bespoke, interactive CNV call visualization browser for every called CNV that offers:

- **Zooming** to the CNV call region in the desired resolution.
- Context **genomic annotations** including chromosomal location and exon and intron positions.
- Local **coverage** information for all samples.
- **Easy linking** to corresponding genomic regions in co-analyzed samples of the cohort.

 

**CNV analysis QC report - *Check sample quality in every analysis***

Informative sample specific features that can affect CNV call quality are included in the analysis QC report:

- **Correlation** to reference samples.

- **Reference sample listing.**

- Cohort **sex** data (if available). Unreliable CNV calls in sex chromosomes are filtered out.

If you would like to see a demonstration of [VarSome Clinical](https://landing.varsome.com/varsome-clinical)'s CNV features, you can [book a time with our sales team here](https://landing.varsome.com/contact).

[View full post](https://updates.varsome.com/en/cnv-calling-enhancements)

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