Version 13.8.1 of VarSome and VarSome Clinical was released on 7 August 2025.

• Minor bug fix to correctly activate PVS1 in cases where the donor or acceptor site is disrupted.
  
• A new VarSome Clinical API endpoint is now available to retrieve the QC report in JSON format.
• "predicted_sex" information in the QC report, now loads faster.
• The "#Sample" card now displays the latest analyses.
• "Estimated Copy Number" calculation for CNVs has been corrected.
• Coding coverage report from gene list sub-analyses has been improved.

Version 13.8.0 of VarSome and VarSome Clinical was released on 31 July 2025.

Summary of Key New Features

• 22 updated databases (full list of databases).
• The dbNSFP update introduces new in-silico predictors now available in VarSome Premium: gMVP, VARITY, ESM1b, ClinPred, PHACTboost, and MutPred2.

Updated Databases

Support

We hope you find these improvements helpful. We would love to hear any feedback and suggestions you may have. Support is available as usual from support@varsome.com.

The VarSome Team.