--- title: VarSome Clinical v.13.19.0.0 description: This release includes performance improvements and new features. image: https://updates.varsome.com/hubfs/release%20banner%20(2).png --- [![VarSome](https://updates.varsome.com/hubfs/VarSome_February2020%20Theme/Images/logo.png)](https://varsome.com/) - Editions - [More about VarSome.com](https://varsome.com/varsome-editions/varsome/) - [More about VarSome Premium](https://varsome.com/varsome-editions/varsome-premium/) - [More about VarSome Clinical](https://varsome.com/varsome-editions/varsome-clinical/) - [Learn more about APIs](https://varsome.com/information/varsome-api-info/) - About - Resources - [Library](https://varsome.com/library/) - [Documentation](https://docs.varsome.com/) - [Query types](https://varsome.com/about/examples/) - [IVDR](https://landing.varsome.com/ivdr-whitepaper) - [Germline Classification](https://varsome.com/about/resources/acmg-implementation/) - [Somatic Classification](https://varsome.com/about/resources/amp-implementation/) - Partners - [Distributors](https://varsome.com/distributors/) - [Partners](https://varsome.com/partners/) - [Become a partner](https://landing.varsome.com/become-varsome-partner) - General - [The Company](https://saphetor.com/about/) - [Cite VarSome](https://varsome.com/about/varsome-citations/) - [Link to VarSome](https://varsome.com/how-do-i-create-link-varsome/) - [Contact](https://landing.varsome.com/contact) - [Community](https://varsome.com/community-contributions/) - [Blog](https://blog.varsome.com/) [Platform Updates](https://updates.varsome.com/en/tag/platform-updates) [VarSome Clinical](https://updates.varsome.com/en/tag/varsome-clinical) [Release](https://updates.varsome.com/en/tag/release) # VarSome Clinical v.13.19.0.0 By [Lyndsey Fletcher](https://updates.varsome.com/en/author/lyndsey-fletcher) on October, 2 2026 ### Categories - Select a Topic - [All](https://updates.varsome.com/en) - [Platform Updates](https://updates.varsome.com/en/tag/platform-updates) - [VarSome Clinical](https://updates.varsome.com/en/tag/varsome-clinical) - [VarSome API](https://updates.varsome.com/en/tag/varsome-api) - [Release](https://updates.varsome.com/en/tag/release) - [VarSome.com Premium](https://updates.varsome.com/en/tag/varsome-com-premium) - [VarSome.com](https://updates.varsome.com/en/tag/varsome-com) - [ACMG](https://updates.varsome.com/en/tag/acmg) ### Stay up to date ##### Search The Blog [Back to main Blog](https://updates.varsome.com/en) ![](https://updates.varsome.com/hs-fs/hubfs/1780856576699.png?height=100&name=1780856576699.png) ###### Lyndsey Fletcher Content Marketer **Version 13.19.0.0 of VarSome Clinical will be released on October 10th 2026.** # Summary of Key New Features: - **Fusion Detection**, **now built in:** Support for Agilent CGP, Roche CGP, Agilent SureSelect XT HS2, Roche KAPA HyperPETE, and RNA-seq. For research use only. - **AND/OR filter complete functionality introduced:** Same filters, new power. - **AMP improvement to return Tier III when there is no curated evidence.** - **VarSome Picks and Actionable genes algorithms now use ACMG SF 3.3.** - **JAX CKB and OncoKB component columns are now searchable/filtered.** # New Features: - **More Complete Somatic Insights with Fusion Calling in VarSome Clinical.** Users can upload their RNA FASTQ file from Agilent CGP, Roche CGP, Agilent SureSelect HS XT2, and Roche KAPA HyperPETE and RNA-seq, and define samples from DNA, RNA, or combined DNA + RNA, enabling flexible analysis workflows. The same pipeline identifies and displays key sample biomarkers — MET exon 14 skipping, EGFR splicing variants, and AR splicing variants — each paired with clinical evidence sourced from CKB, OncoKB, CIViC, and AACT clinical trials. Detected fusions appear in a dedicated fusion table, while sample biomarkers are displayed as cards above it for quick reference. ![](https://updates.varsome.com/hs-fs/hubfs/undefined-Sep-30-2026-02-58-04-7121-PM.png?width=2048&height=984&name=undefined-Sep-30-2026-02-58-04-7121-PM.png) By adding fusion detection, VarSome Clinical extends the reach of its somatic platform beyond DNA-based variant calling into RNA-level alterations that are often missed by DNA sequencing alone. This gives users a more complete molecular picture of each patient case in a single workflow, surfacing clinically actionable events with evidence from leading knowledgebases already attached. This feature is currently available **for research use only.** - **Filter Smarter, Query with Precision: Introducing AND/OR filter complete functionality.** This release introduces the complete, redesigned filtering engine, built to support complex logical expressions through AND/OR combinations across multiple filter conditions. The new UI lets users construct multi-layered filter rules with explicit control over how each condition relates to the others, enabling more precise and flexible querying of clinically relevant variants. The redesigned filters can now be saved for future use. All previously saved filter sets are automatically migrated to the new AND/OR model — each migrated as a single AND-connected group by default — ensuring continuity and backward compatibility, with no loss of existing filters, while unlocking the ability to edit them using the new logic-based UI. ![](https://updates.varsome.com/hs-fs/hubfs/undefined-Sep-30-2026-03-01-36-3501-PM.png?width=2048&height=989&name=undefined-Sep-30-2026-03-01-36-3501-PM.png) ![](https://updates.varsome.com/hs-fs/hubfs/undefined-Sep-30-2026-03-01-55-2678-PM.png?width=2048&height=1382&name=undefined-Sep-30-2026-03-01-55-2678-PM.png) By combining filters using AND / OR relationships, users can precisely define the conditions that matter most to them, narrowing down variants with greater accuracy and confidence. Users also gain full control over how conditions are combined and evaluated. For example, users can filter for variants that meet condition A and condition B simultaneously, or cast a wider net by retrieving variants that meet either condition A or condition B, all within a single, coherent filter set. - **AMP improvement to return Tier III when there is no curated evidence.** In previous versions, the classification logic treats an *absent* drug/treatment evidence result as equivalent to a *negative* one, causing the Drug & Treatment rule to return Tier IV if no curated drug evidence exists in CKB, CIViC, or OncoKB. Because Tier IV is also the designated "no override" fallback signal in the overall tier calculation, this conflation incorrectly suppresses the Germline + Pathway + Drug fallback path, forcing the overall verdict to Tier IV even when a variant is P/LP in a cancer-relevant pathway and would otherwise resolve to Tier III. This improvement restores the intended separation between "no evidence" and "evidence indicates benign". - **VarSome Picks and Actionable genes algorithms now use ACMG SF 3.3.** VarSome Picks and Actionable Genes are aligned with the latest ACMG SF list, ensuring that customers are working against the most current, professionally vetted standard for secondary findings, without needing to track guideline updates themselves or manually reconfigure gene panels. The addition of ABCD1, CYP27A1, and PLN means users can now identify clinically actionable secondary findings in these genes automatically, as soon as they're flagged as opportunistic screening targets by the ACMG. This reduces the risk of clinically significant findings being missed, and it reinforces confidence that VarSome's actionability logic reflects current best practice in clinical genomics, with zero disruption to existing workflows; all prior SF v3.2 gene-phenotype pairs and reporting behavior are preserved unchanged. - **JAX CKB and OncoKB component columns are now searchable/filtered.** JaxCKB and OncoKB component columns are now filterable by tier, approval status, tumor type, and associated drug. This allows users to quickly see available evidence, streamlining clinical evidence interpretation. # Other Features - **User permission - CNV analysis access for assigned samples is now retroactive.** The main CNV analysis will now be inherited once the sample with CNV results is assigned to a user. - **TMB and MSI is now available for Twist Tumor Panel V8.** - **The Max read ratio value in the CNV browser is now customizable.** A new Filters toggle is now available in the top-right corner of the Read Ratio window; this allows users to set a custom Max Read Ratio value, providing control over the Y-axis scale. - **VarSome Clinical version is now added when clinical reports are generated.** # Support We hope you find these improvements helpful. We would love to hear any feedback and suggestions you may have. Support is available as usual from [support@varsome.com.](mailto:support@varsome.com)   The VarSome Team. 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