On 6 March 2026 we will be releasing the Q1 API changes for the VarSome API (stable-api.varsome.com).
The Stable API will update version 13.12.2 to version 13.14.1 with data frozen as of the
4th February 2026. This version has been successfully used in production for over a month.
The most recent version, used by VarSome itself, is always available at api.varsome.com.
Database Updates
The following databases have been updated:
|
Source |
Data Type |
Current version (Staging, Q4 '25) |
Next release (Staging, Q1 '26) |
|---|---|---|---|
|
UniProt Regions |
Region |
07-Jul-2025 |
07-Nov-2025 |
|
RefSeq |
Transcripts |
228 |
232 |
|
PharmGKB |
Variant |
07-Sep-2025 |
07-Jan-2026 |
|
OncoKB |
Gene |
v5.1 |
v5.4 |
|
OMIM® |
Gene |
16-Sep-2025 |
19-Jan-2026 |
|
OMIM® |
Variant |
16-Sep-2025 |
19-Jan-2026 |
|
OMIM® |
Phenotype |
16-Sep-2025 |
19-Jan-2026 |
|
Mondo |
Phenotype |
07-Feb-2025 |
07-Nov-2025 |
|
LOVD |
Gene |
16-Sep-2025 |
19-Jan-2026 |
|
LOVD |
Variant |
16-Sep-2025 |
19-Jan-2026 |
|
HGNC |
Genes |
13-Feb-2025 |
07-Nov-2025 |
|
GWAS |
Genes |
07-Sep-2025 |
07-Jan-2026 |
|
ClinVar CNVs |
Region |
07-Jul-2025 |
07-Jan-2026 |
|
ClinVar |
Variant |
07-Jul-2025 |
07-Jan-2026 |
|
ClinGen Variants |
Variant |
07-Sep-2025 |
07-Jan-2026 |
|
ClinGen Regions |
Region |
07-Sep-2025 |
07-Jan-2026 |
|
ClinGen Disease Validity |
Gene |
07-Sep-2025 |
07-Jan-2026 |
|
ClinGen CNVs |
Region |
07-Sep-2025 |
07-Jan-2026 |
|
ClinGen |
Gene |
07-Sep-2025 |
07-Jan-2026 |
|
CKB |
Variant |
07-Oct-2025 |
19-Jan-2026 |
|
CKB |
Gene |
07-Oct-2025 |
19-Jan-2026 |
|
CIViC |
Variant |
07-Oct-2025 |
19-Jan-2026 |
|
CIViC |
Gene |
07-Oct-2025 |
19-Jan-2026 |
|
AACT |
Gene |
07-Oct-2025 |
07-Jan-2026 |
|
CPIC |
Gene |
07-Mar-2025 |
07-Jan-2026 |
|
dbSNP |
Variant |
Build 156 |
Build 157 |
|
dbVar |
Region |
07-Jun-2025 |
07-Nov-2025 |
|
DECIPHER |
Region |
07-Sep-2025 |
07-Jan-2026 |
|
Ensembl |
Transcript |
113 |
115 |
|
Gene2Phenotype |
Gene |
07-Sep-2025 |
07-Jan-2026 |
|
GHR |
Gene |
07-Sep-2025 |
07-Jan-2026 |
|
ACMG Classifier |
Variant |
13.12.2 |
13.14.1 |
|
AMP Classifier |
Variant |
13.12.2 |
13.14.1 |
|
KnownPathogenic |
Variant |
21-Oct-2025 |
28-Jan-2026 |
JSON Schema Changes
Variants
### New Endpoints: None
-----------------------
### Deleted Endpoints: None
---------------------------
### Modified Endpoints: 1
-------------------------
POST /lookup/batch/{ref_genome}
- Request body changed
- Content changed
- Modified media type: application/json
- Schema changed
- Properties changed
- Modified property: variants
- MaxItems changed from 200 to 50
Genes
### New Endpoints: None
-----------------------
### Deleted Endpoints: None
---------------------------
### Modified Endpoints: 1
-------------------------
POST /genes/batch/{ref_genome}
- Request body changed
- Content changed
- Modified media type: application/json
- Schema changed
- Properties changed
- Modified property: genes
- MaxItems changed from 100 to 10
CNVs
No changes.
Please contact us if you need any further assistance with this release.
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