VarSome API Release

VarSome API Update - v. 13.14.1

By Xanthippi Papakonstanti on February, 26 2026

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Xanthippi Papakonstanti

On 6 March 2026 we will be releasing the Q1 API changes for the VarSome API (stable-api.varsome.com).

The Stable API will update version 13.12.2 to version 13.14.1 with data frozen as of the
4th February 2026. This version has been successfully used in production for over a month.

The most recent version, used by VarSome itself, is always available at api.varsome.com.

Database Updates

The following databases have been updated:

Source

Data Type

Current version

(Staging, Q4 '25)

Next release

(Staging, Q1 '26)

UniProt Regions

Region

07-Jul-2025

07-Nov-2025

RefSeq

Transcripts

228

232

PharmGKB

Variant

07-Sep-2025

07-Jan-2026

OncoKB

Gene

v5.1

v5.4

OMIM®

Gene

16-Sep-2025

19-Jan-2026

OMIM®

Variant

16-Sep-2025

19-Jan-2026

OMIM®

Phenotype

16-Sep-2025

19-Jan-2026

Mondo

Phenotype

07-Feb-2025

07-Nov-2025

LOVD

Gene

16-Sep-2025

19-Jan-2026

LOVD

Variant

16-Sep-2025

19-Jan-2026

HGNC

Genes

13-Feb-2025

07-Nov-2025

GWAS

Genes

07-Sep-2025

07-Jan-2026

ClinVar CNVs

Region

07-Jul-2025

07-Jan-2026

ClinVar

Variant

07-Jul-2025

07-Jan-2026

ClinGen Variants

Variant

07-Sep-2025

07-Jan-2026

ClinGen Regions

Region

07-Sep-2025

07-Jan-2026

ClinGen Disease Validity

Gene

07-Sep-2025

07-Jan-2026

ClinGen CNVs

Region

07-Sep-2025

07-Jan-2026

ClinGen

Gene

07-Sep-2025

07-Jan-2026

CKB

Variant

07-Oct-2025

19-Jan-2026

CKB

Gene

07-Oct-2025

19-Jan-2026

CIViC

Variant

07-Oct-2025

19-Jan-2026

CIViC

Gene

07-Oct-2025

19-Jan-2026

AACT

Gene

07-Oct-2025

07-Jan-2026

CPIC

Gene

07-Mar-2025

07-Jan-2026

dbSNP

Variant

Build 156

Build 157

dbVar

Region

07-Jun-2025

07-Nov-2025

DECIPHER

Region

07-Sep-2025

07-Jan-2026

Ensembl

Transcript

113

115

Gene2Phenotype

Gene

07-Sep-2025

07-Jan-2026

GHR

Gene

07-Sep-2025

07-Jan-2026

ACMG Classifier

Variant

13.12.2

13.14.1

AMP Classifier

Variant

13.12.2

13.14.1

KnownPathogenic

Variant

21-Oct-2025

28-Jan-2026

 

JSON Schema Changes

Variants

### New Endpoints: None

-----------------------

 

### Deleted Endpoints: None

---------------------------

 

### Modified Endpoints: 1

-------------------------

POST /lookup/batch/{ref_genome}

- Request body changed

  - Content changed

    - Modified media type: application/json

      - Schema changed

        - Properties changed

          - Modified property: variants

             - MaxItems changed from 200 to 50



 

Genes

### New Endpoints: None

-----------------------

 

### Deleted Endpoints: None

---------------------------

 

### Modified Endpoints: 1

-------------------------

POST /genes/batch/{ref_genome}

- Request body changed

  - Content changed

    - Modified media type: application/json

      - Schema changed

        - Properties changed

          - Modified property: genes

            - MaxItems changed from 100 to 10

 

CNVs

No changes.


Please contact us if you need any further assistance with this release.

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