On 5 December 2025 we will be releasing the Q4 API changes for the VarSome API (stable-api.varsome.com).
The Stable API will update version 13.8.0 to version 13.12.2 with data frozen as of the
7 November 2025. This version has been successfully used in production for over a month.
The most recent version, used by VarSome itself, is always available at api.varsome.com.
The following databases have been updated:
|
Source |
Data Type |
Current version (Staging, Q3 '25) |
Next release (Staging, Q4 '25) |
|
GnomAD STR |
gene |
N/A |
23-Aug-2025 |
|
AACT |
gene |
07-Apr-2024 |
07-Oct-2025 |
|
ACMG Classifier |
variant |
13.8.0 |
13.12.2 |
|
AMP Classifier |
variant |
13.8.0 |
13.12.2 |
|
GWAS |
variant |
07-Apr-2025 |
07-Sep-2025 |
|
gene2phenotype |
gene |
07-Sep-2025 |
07-Sep-2025 |
|
DECIPHER |
region / CNV |
07-Aug-2025 |
07-Sep-2025 |
|
Pharmacogenomic Biomarkers |
gene |
19-Sep-2022 |
07-Oct-2025 |
|
GenCC |
gene |
07-Apr-2025 |
07-Aug-2025 |
|
OMIM® |
gene |
16-Aug-2025 |
16-Sep-2025 |
|
OMIM® |
variant |
16-Aug-2025 |
16-Sep-2025 |
|
LOVD |
variant |
16-Aug-2025 |
16-Sep-2025 |
|
LOVD |
gene |
16-Aug-2025 |
16-Sep-2025 |
|
OncoKB™ |
variant |
N/A |
v5.1 |
|
ClinGen |
Disease Validity |
07-Aug-2025 |
07-Sep-2025 |
|
ClinGen |
variant |
07-Aug-2025 |
07-Sep-2025 |
|
ClinGen |
gene |
07-Aug-2025 |
07-Sep-2025 |
|
ClinGen |
region / CNV |
07-Aug-2025 |
07-Sep-2025 |
|
GHR |
gene |
07-Aug-2025 |
07-Sep-2025 |
|
PharmGKB |
gene |
07-Aug-2025 |
07-Oct-2025 |
|
PharmGKB |
variant |
07-Aug-2025 |
07-Oct-2025 |
|
CIViC |
gene |
08-Dec-2023 |
07-Oct-2025 |
|
CIViC |
variant |
08-Dec-2023 |
07-Oct-2025 |
|
Known Pathogenic |
gene |
30-Jul-2025 |
06-Nov-2025 |
|
Known Pathogenic |
variant |
30-Jul-2025 |
06-Nov-2025 |
## POST /lookup/batch/{ref_genome}
- :warning: the 'wustl_civic/items/items/items/molecular_profiles/items/molecular_profile/variant/items/variant_ids/items/' response's property type/format changed from 'integer'/'' to 'string'/'' for status '201'
## GET /lookup/{spec_query}/{ref_genome}
- :warning: the 'wustl_civic/items/items/items/molecular_profiles/items/molecular_profile/variant/items/variant_ids/items/' response's property type/format changed from 'integer'/'' to 'string'/'' for status '200'
- added the new enum value 'gnomad-str' to the 'query' request parameter 'add-source-databases'
- added the new enum value 'gnomad-str' to the 'query' request parameter 'exclude-source-databases'
## GET /gene/{gene_symbol}/{ref_genome}
- :warning: the response property 'jax_ckb/version' became optional for the status '200'
- :warning: removed the optional property 'ebi_gene_2_phenotype/items/items/organs' from the response with the '200' status
## POST /genes/batch/{ref_genome}
- :warning: the response property 'jax_ckb/version' became optional for the status '201'
- :warning: removed the optional property 'ebi_gene_2_phenotype/items/items/organs' from the response with the '201' status
No changes.
Please contact us if you need any further assistance with this release.