VarSome API Update - v. 12.5.1

On 4th September 2026 we will be releasing the Q3 API changes for the VarSome API (stable-api.varsome.com).

The Stable API will update version 12.1.1 to version 12.5.1. with data frozen as of the
7th August 2026. This version has been successfully used in production for over a month.

The most recent version, used by VarSome itself, is always available at api.varsome.com.

Database Updates

The following databases have been updated:

API Changelog 12.1.1 vs. 12.5.1

Variants

POST /lookup/batch/{ref_genome}

• added the optional property acmg_annotation/throttling_info/full_data_queries to the response with the 201 status
• added the optional property amp_annotation/throttling_info/full_data_queries to the response with the 201 status
• added the optional property dbnsfp/items/misfit_d_pred_lenient to the response with the 201 status
• added the optional property dbnsfp/items/misfit_d_pred_stringent to the response with the 201 status
• added the optional property dbnsfp/items/misfit_d_rankscore to the response with the 201 status
• added the optional property dbnsfp/items/misfit_d_score to the response with the 201 status
• added the optional property dbnsfp/items/misfit_s_rankscore to the response with the 201 status
• added the optional property dbnsfp/items/misfit_s_score to the response with the 201 status
• added the optional property dbnsfp/items/popeve_converted_rankscore to the response with the 201 status
• added the optional property dbnsfp/items/popeve_pred to the response with the 201 status
• added the optional property dbnsfp/items/popeve_score to the response with the 201 status
• added the optional property population_frequency_databases to the response with the 201 status
• added the required property acmg_annotation/throttling_info/max_queries to the response with the 201 status
• added the required property amp_annotation/throttling_info/max_queries to the response with the 201 status

GET /lookup/{spec_query}/{ref_genome}

• added the new optional query request parameter use-mane-select-transcript
• added the optional property acmg_annotation/throttling_info/full_data_queries to the response with the 200 status
• added the optional property amp_annotation/throttling_info/full_data_queries to the response with the 200 status
• added the optional property dbnsfp/items/misfit_d_pred_lenient to the response with the 200 status
• added the optional property dbnsfp/items/misfit_d_pred_stringent to the response with the 200 status
• added the optional property dbnsfp/items/misfit_d_rankscore to the response with the 200 status
• added the optional property dbnsfp/items/misfit_d_score to the response with the 200 status
• added the optional property dbnsfp/items/misfit_s_rankscore to the response with the 200 status
• added the optional property dbnsfp/items/misfit_s_score to the response with the 200 status
• added the optional property dbnsfp/items/popeve_converted_rankscore to the response with the 200 status
• added the optional property dbnsfp/items/popeve_pred to the response with the 200 status
• added the optional property dbnsfp/items/popeve_score to the response with the 200 status
• added the optional property population_frequency_databases to the response with the 200 status
• added the required property acmg_annotation/throttling_info/max_queries to the response with the 200 status
• added the required property amp_annotation/throttling_info/max_queries to the response with the 200 status

Genes

API Changes

GET /gene/{gene_symbol}/{ref_genome}

• added the optional property protein_atlas/general_info/rna_specific_ptpm to the response with the 200 status

POST /genes/batch/{ref_genome}

• added the optional property protein_atlas/general_info/rna_specific_ptpm to the response with the 201 status

GET /phenotype-information/

• endpoint added

GET /phenotype-information/{object_id}/

• endpoint added

CNVs

GET /cnv/{query}/{ref_genome}

• added the optional property throttling_info/full_data_queries to the response with the 200 status
• added the required property throttling_info/max_queries to the response with the 200 status

Please contact us if you need any further assistance with this release.