On 7th June 2024 we will be releasing the Q2 API changes for the VarSome API (stable-api.varsome.com).
The Stable API will update version 11.10 to version 11.15 with data frozen as of the 8th May 2024. This version has been successfully used in production for over a month.
The most recent version, used by VarSome itself, is always available at api.varsome.com.
Database Updates
The following databases have been updated:
|
Database name |
Data Type |
Current (Stable, Q1 '24) |
Next Release (Staging, Q2 '24) |
|
AACT |
gene |
05-Jan-2024 |
01-Apr-2024 |
|
ACMG classifier |
variant |
11.10 |
11.15 |
|
AMP classifier |
variant |
11.10 |
11.15 |
|
HPO |
disease |
13-Jul-2023 |
07-Mar-2024 |
|
Ensembl |
transcript |
110 |
111 |
|
Mondo |
disease |
13-Jul-2023 |
21-Mar-2024 |
|
ClinVar |
variant |
15-Jan-2024 |
01-Apr-2024 |
|
ClinVar |
region / CNV |
08-Dec-2023 |
01-Apr-2024 |
|
CPIC |
gene |
05-Jan-2024 |
01-Apr-2024 |
|
dbNSFP |
variant |
4.5 |
4.7 |
|
GHR |
gene |
15-Jan-2024 |
01-Mar-2024 |
|
GWAS |
variant |
08-Dec-2023 |
07-Feb-2024 |
|
HGNC |
gene |
12-Dec-2023 |
17-Apr-2024 |
|
LOVD |
variant |
15-Jan-2024 |
17-Apr-2024 |
|
ClinGen |
variant |
15-Jan-2024 |
01-Apr-2024 |
|
ClinGen |
gene |
19-Dec-2023 |
01-Apr-2024 |
|
ClinGen |
region / CNV |
19-Dec-2023 |
01-Apr-2024 |
|
ClinGen |
Disease Validity |
07-Jun-2022 |
08-Feb-2024 |
|
OMIM |
gene |
04-Jan-2024 |
17-Apr-2024 |
|
OMIM |
variant |
04-Jan-2024 |
17-Apr-2024 |
|
PharmGKB |
gene |
15-Jan-2024 |
01-Apr-2024 |
|
PharmGKB |
variant |
15-Jan-2024 |
01-Apr-2024 |
|
PMKB |
variant |
15-Jan-2024 |
08-Apr-2024 |
|
The Human Protein Atlas |
gene |
05-Jan-2024 |
14-Mar-2024 |
|
RefSeq |
transcript |
221 |
223 |
|
DECIPHER |
region / CNV |
08-Dec-2023 |
01-Apr-2024 |
|
Known Pathogenic |
gene |
02-Jan-2024 |
07-May-2024 |
|
Known Pathogenic |
variant |
02-Jan-2024 |
07-May-2024 |
|
Pubmed |
variant |
02-Jan-2024 |
07-May-2024 |
|
Pubmed |
gene |
02-Jan-2024 |
07-May-2024 |
|
UniProt Variants |
variant |
08-Dec-2023 |
01-Apr-2024 |
JSON Schema Changes
Reminder: all the data structures returned by the VarSome API are documented here.
Variant Annotation Schema Changes
Response modifications
The response changes in this section concern both GET /lookup/{spec_query}/{ref_genome} and POST /lookup/batch/{ref_genome} requests.
The wustil_civic attribute in the responses has been modified to include additional information:
"molecular_profile_civic_url": "string",
"molecular_profiles": [
{
"molecular_profile": {
"evidence_item_ids": [
0
],
"name": "string",
"summary": "string",
"variant": [
{
"variant_ids": []
}
]
},
"molecular_profile_civic_id": 0
}
]
Please contact us if you need any further assistance with this release.
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